Buy4

Rapport Therapeutics, Inc.

RAPP

Total Value

$20.4M

Net $20.4M bought

Filing Date

Oct 30, 2026

4 transactions

Purchases

$20.4M

4 transactions

Trade Summary

On Oct 28, 2026, HEALY JAMES, Director, purchased $20.4M of Rapport Therapeutics, Inc. (RAPP) across 4 transactions. The filing covers Common Stock and reflects net buying of $20.4M. Reported prices ranged from $21.00. Insider transactions are sourced from SEC Form 4 disclosures and should be reviewed alongside company fundamentals and the insider's broader trading history.

Price at the Time of the Trade

RAPP daily price with the insider's purchase marked at $21.00.

Bought near the 6-month low · the stock trades 19% higher today.

Price data is delayed and provided for context only — not investment advice.

Insider Information

Name: HEALY JAMES
Role: Director
Location: MENLO PARK, CA

Filing Details

Filing Date: Oct 30, 2026
Transaction Date: Oct 28, 2026
Accession Number: 0001104659-26-120789
Form Type: 4
Net Trading Amount: $20.4M

Non-Derivative Transactions

Date	Security	Shares	Price	Type	Value
Oct 28, 2026	Common Stock	952,380	$21.00	Purchase	$20.0M
Oct 28, 2026	Common Stock	6,395	$21.00	Purchase	$134.3K
Oct 28, 2026	Common Stock	3,772	$21.00	Purchase	$79.2K
Oct 28, 2026	Common Stock	6,933	$21.00	Purchase	$145.6K

Want live alerts when HEALY JAMES trades again?

Download Insider Trades to track RAPP, follow insiders, and get mobile alerts when new SEC Form 4 filings are published.

iOS App Android App

Footnotes

(F1)The shares are directly held by Sofinnova Venture Partners XI, L.P. ("SVP XI"). Sofinnova Management XI, L.P. ("SM XI LP") is the general partner of SVP XI and Sofinnova Management XI, L.L.C. ("SM XI") is the general partner of SM XI LP. The Reporting Person is a managing member of SM XI and may be deemed to share voting and dispositive power over the shares held by SVP XI. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.
(F2)The shares are directly held by SummitTX Master, SPC - SummitTX Apex SP - Healthcare 3 (f/k/a Crestline Summit Master, SPC - Crestline Summit Apex SP) ("Apex SP"). Sofinnova BioEquities GP LLC ("BioEquities GP") is the general partner of Apex SP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Apex SP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.
(F3)The shares are directly held by SummitTX Master, SPC - SummitTX Alpha SP - Healthcare 3 (f/k/a Crestline Summit Master, SPC - PEAK SP) ("Alpha SP"). BioEquities GP is the general partner of Alpha SP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Alpha SP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.
(F4)The shares are directly held by SummitTX Pinnacle Master, L.P. - Healthcare 3 (f/k/a Crestline Summit Pinnacle Master, L.P.) ("Pinnacle LP"). BioEquities GP is the general partner of Pinnacle LP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Pinnacle LP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

HEALY JAMES

(Last)

(First)

(Middle)

SOFINNOVA INVESTMENTS, INC.

3000 SAND HILL ROAD, BLDG. 3, SUITE 150

(Street)

MENLO PARK

94025

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Rapport Therapeutics, Inc. [ RAPP ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
10/28/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	10/28/2026		P		952,380	A	$21	2,815,707	I	By Sofinnova Venture Partners XI, L.P.⁽¹⁾
Common Stock	10/28/2026		P		6,395	A	$21	17,990	I	By SummitTX Master, SPC -SummitTX Apex SP - Healthcare 3⁽²⁾
Common Stock	10/28/2026		P		3,772	A	$21	14,924	I	By SummitTX Master, SPC - SummitTX Alpha SP - Healthcare 3⁽³⁾
Common Stock	10/28/2026		P		6,933	A	$21	25,267	I	By SummitTX Pinnacle Master, L.P. - Healthcare 3⁽⁴⁾

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:

1. The shares are directly held by Sofinnova Venture Partners XI, L.P. ("SVP XI"). Sofinnova Management XI, L.P. ("SM XI LP") is the general partner of SVP XI and Sofinnova Management XI, L.L.C. ("SM XI") is the general partner of SM XI LP. The Reporting Person is a managing member of SM XI and may be deemed to share voting and dispositive power over the shares held by SVP XI. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

2. The shares are directly held by SummitTX Master, SPC - SummitTX Apex SP - Healthcare 3 (f/k/a Crestline Summit Master, SPC - Crestline Summit Apex SP) ("Apex SP"). Sofinnova BioEquities GP LLC ("BioEquities GP") is the general partner of Apex SP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Apex SP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

3. The shares are directly held by SummitTX Master, SPC - SummitTX Alpha SP - Healthcare 3 (f/k/a Crestline Summit Master, SPC - PEAK SP) ("Alpha SP"). BioEquities GP is the general partner of Alpha SP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Alpha SP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

4. The shares are directly held by SummitTX Pinnacle Master, L.P. - Healthcare 3 (f/k/a Crestline Summit Pinnacle Master, L.P.) ("Pinnacle LP"). BioEquities GP is the general partner of Pinnacle LP. The Reporting Person is a managing member of BioEquities GP and may be deemed to share voting and dispositive power over the shares held by Pinnacle LP. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

	/s/ Nathalie Auber, Attorney-in-Fact	10/30/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

Form 4 as rendered by the SEC from accession 0001104659-26-120789.

Rapport Therapeutics, Inc.

Trade Summary

Price at the Time of the Trade

Company Information

Insider Information

Filing Details

Non-Derivative Transactions

Want live alerts when HEALY JAMES trades again?

Footnotes

SEC Form 4

SEC Filing

Price at the Time of the Trade

SEC Form 4